Variability of ZAP 70 expression in a patient with CLL

The Biological Relevance of ZAP-70 in CLL

ZAP-70 methylation status is associated with ZAP-70 expression status in chronic lymphocytic leukemia.

BACKGROUND AND OBJECTIVES ZAP-70 expression is a recognized prognostic marker in chronic lymphocytic leukemia (CLL). The aim of this study was to analyze whether the methylation status of the ZAP-70 gene is associated with expression of the ZAP-70 protein. DESIGN AND METHODS Patients with CLL (n=87), acute lymphoblastic leukemia (n=13), mantle cell leukemia (n=13) and splenic marginal zone ly...

ZAP-70 expression in B-cell hematologic malignancy is not limited to CLL/SLL.

ZAP-70 is a tyrosine kinase expressed in normal T cells and NK cells. Expression of ZAP-70 has been associated with poor prognosis in B-cell chronic lymphocytic leukemia and might be a surrogate marker for immunoglobin heavy chain (IGH) mutational status in that disease. Little is known about ZAP-70 expression in other hematologic malignant neoplasms. We examined 446 specimens representing a ra...

Clinical Significance of ZAP-70 Protein Expression in B-cell Chronic Lymphocytic Leukemia Short title: ZAP-70 and prognosis in B-CLL

Prepublished online April 6, 2006; Amadori Gattei, Paolo de Fabritiis, Maria Cantonetti, Francesco Lo Coco, Domenico Del Principe and Sergio Ottaviani, Paola Panetta, Antonio Bruno, Riccardo Bomben, Giovanna Suppo, Massimo Degan, Valter Licia Antonella Zucchetto, Rita Marini, Pasquale Niscola, Maria Antonietta Irno Consalvo, Carla Mazzone, Maria Ilaria Del Principe, Giovanni Del Poeta, Francesc...

NEOPLASIA CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potential

1Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Turin, Italy; 2Research Center for Experimental Medicine (CeRMS), University of Torino Medical School, Turin, Italy; 3Department of Medicine and Experimental Oncology, University of Torino Medical School, Turin, Italy; 4Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione G. Pascale, Naples...